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The structure and composition of the SC in AD condition can be influenced in the subsequent ways [14]: Loss or decreased function of filaggrin protein (FLG) Enhanced serine protease activity Damaged lipid processing

Model refinement against local maps was accomplished using PHENIX for real-space refinement 58

Similar observations were noted in later human studies [56, 57], with the peak serum TMAO observed within hours following oral administration of the tracer [56]

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