Monolayers of hiPSC-derived endothelial cells from Alzheimer's patients with PSEN1 and PSEN2 mutations, differentiated with a chemically defined medium, possessed a low TEER, reduced expression of claudin-5, occludin, and ZO1 protein, and impaired glucose transport (Raut et al., 2021)
The main ongoing studies: REDEFINE 1 , Phase 3 obesity without T2D (results 20242025, preliminarily 25.3 %) REDEFINE 2 , Phase 3 obesity + T2D REDEFINE 3 , Phase 3 cardiovascular outcome trial (n~7000) Stand-alone clinical development of Cagrilintide is limited , Novo Nordisk is primarily investing in the CagriSema combination
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