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When administered directly into the cerebrospinal fluid of mice, it showed dose-dependent pain-relieving effects that were blocked by naloxone, confirming involvement of opioid pathways

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doi: 10.1186/s12974-023-02879-7 377 WeinhausB.HomanS.KincaidM.TadwalkarA.GuX.KumarS.et al

Dexamethasone decreased their expression levels, and the combination of dexamethasone and pefloxacin downregulated not only the expression levels of Col1a1 and Col3a1 but also those of various other collagen subtypes (Supplementary Figure S2B)