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Sedating Antihistamines (Diphenhydramine/Doxylamine) Mechanism: Antihistamines block H1 receptors, causing drowsiness

In children, these medications can be associated with significant adverse effects, including detrimental changes in body weight as well as triglyceride, cholesterol, and blood glucose concentrations within a short time (6) and they also increase the risk of type 2 diabetes (7)

Semaglutide activates both Gs- and Gq-signaling pathways in GLP-1R-expressing hindbrain neurons, driving increases in the secondary messenger cyclic AMP (cAMP) that suppress feeding behavior and reduce total energy intake

A provider can review medication use, nutrition, activity, side effects, lab work, and whether another treatment option may be appropriate

Neither of the drugs resulted in a permanent regression of the tumor