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Interestingly, adult mice with modest isolated elevations in GH and IGF-1 levels have greater lean mass, improved lipid oxidation and glucose clearance 38 , while specific, temporal reductions in GH and IGF-1 in adults have been linked to deleterious metabolic effects, including impaired hepatic insulin action 38 , and reduced -cell mass and function 39

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The predominant body of knowledge related to its function, which differs between cell types, is tied to its expression in hepatocytes and various epithelial, endothelial, and hematopoietic cells, as reviewed in detail elsewhere [20, 22, 44, 81]

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