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The system Xc, a dimer consisting of SLC7A11 and SLC3A2, exchanges glutamate (Glu) out of the cell and cystine into the cell at a ratio of 1:1 [27, 28]

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Its high sensitivity and specificity are offset by challenges such as the requirement for large DNA amounts and the risk of artifactual oxidation during sample preparation (Gonzalez-Hunt et al., 2018)

Subsequently, a Phase IIa study was conducted in 2013 (ClinicalTrials.gov ID: NCT01926444) involving 240 patients

However, depending on skin type and dosage, noticeable improvements usually show up after 10 to 15 sessions