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The molecular structure of GHK-Cu features a tripeptide sequence (Gly-His-Lys) with high affinity for copper(II) ions, forming a stable 1:1 complex with a dissociation constant in the nanomolar range
Glycine and serine (serine is converted to glycine for GSH synthesis) are spent making GSH, but glutamate is increased once GSH exits the cell and is transaminated by GGT, releasing glutamate into circulation
Thus, this population is critical to managing blood pressure, regulating the prothrombotic state, and controlling blood glucose
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