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In the acute phase, the allergens cross the immune barrier and stimulate a T helper (Th) 2 response with the production of IL-4, IL-13, IL-22 and IL-31

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The mechanism is not fully understood but it is believed that the increased intracellular glutathione levels and increased ROS 217 are closely coupled with the build-up of toxic lipid peroxides and consequent ferroptosis

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217 In addition, a double-blind, placebo-controlled, crossover trial with 23 participants reported that taking 200 mg CoQ10 daily did not affect exercise performance or markers of exercise-induced oxidative stress in hemodialysis patients