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W., McDermott, B

Alcoholic liver disease: Chronic alcohol consumption severely depletes hepatic glutathione through multiple mechanisms: increased ROS production during ethanol metabolism, reduced cysteine availability, and impaired mitochondrial glutathione transport

As the major intracellular antioxidant, it also plays a role in removing toxins and carcinogens from the body

At the skin level, glutathione may influence melanin production by partially inhibiting certain enzymes involved in pigmentation