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Similar results were reported with quercetin (181, 182)

These may include an increase in blood pressure and heart rate, difficulties with sleep such as insomnia, feelings of nervousness and restlessness, and the potential for dependence, abuse, or withdrawal symptoms with prolonged use

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While cross-sectional studies show correlations between circadian disruption and age-related diseases, we need more longitudinal studies to determine if circadian improvements can delay the onset of those diseases