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Seminars in Thoracic and Cardiovascular Surgery, 2017

Protection Against Chronic Diseases Glutathiones antioxidant properties help reduce the risk of chronic diseases, such as cardiovascular disease, diabetes, and cancer

202,203 Essentially, the imported disulphide-containing proteins undergo cathepsin-catalysed degradation in the lysosome, leading to the formation of cystine, which is then effluxed by the cystinosin transporter into the cytosol, where it is reduced to cysteine in a process that requires NADPH, leading to the formation of oxidised glutathione