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Perioperative implications were evaluated with emphasis on orthopaedic surgical risk domains relevant to total joint arthroplasty (TJA), including wound complications, hematoma formation, immune modulation, infection susceptibility, heterotopic ossification, and implant fixation considerations

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Marsh SA, Powell PC, Dellitalia LJ, Chatham JC (2013) Cardiac O-GlcNAcylation blunts autophagic signaling in the diabetic heart

However, as we get older, or when we face high levels of stress, our natural production of this vital molecule tends to decline

Recent genetic studies demonstrated accumulation of altered gene products in various tissues starting from the age of 2025 [64]