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While the employed rodent model replicates key metabolic and histopathological features of the human condition, and the conservation of the identified target pathways between species supports the biological plausibility of our findings, several critical aspects remain to be fully addressed

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Cold serum can be uncomfortable on skin and may absorb less effectively

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However, the promotion or inhibition of HO-1 for ferroptosis has obtained contradictory results, so the relationship between them needs to be further explored [41, 42]