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In the past two decades, high quality genetic, transcriptomic, protein, enzymatic, and pharmacotherapeutic studies have consistently highlighted reduced mitochondrial function associated with bipolar depression

Targeting Fibrosis Directly targeting the fibrotic process offers another therapeutic avenue, particularly relevant for addressing pain and structural damage caused by adhesions and tissue scarring [87]

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Some patients with joint pain also have surrounding soft-tissue irritation, and that periarticular tissue may respond