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Pharmacother 57, 145 (2003)

19 Here, we show that elevated caffeine levels in RBC units are consistently associated with a metabolic phenotype indicative of compromised glycolytic activity, reduced ATP, total adenylate pools and 2,3-BPG, as well as with heightened oxidative stress, ferroptosis-like processes 36 and markers of osmotic fragility, including oxidized glutathione, 37 lipid peroxidation products 36 and hydroxyacyl-carnitines, 38 hypoxanthine 8 and kynurenine

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Cell Biol Int

C9orf72 protein can be recognized by T cells as an autoantigen, and this ALS-associated T cell autoreactivity was found broadly in ALS patients, though it was particularly high in C9orf72 mutation carriers (Michaelis et al., 2025)