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Knowing these potential complications helps set realistic expectations and highlights the importance of proper planning and aftercare

Different tools including the Cochrane risk of bias tool for randomized controlled trials (RCTs) 31 , methodological item for non-randomized studies (MINORS) for quasi-experimental studies 32 , the National Heart Lung and Blood Institute (NIH) quality assessment tool for cross-sectional studies 33 , NIH quality assessment tool for pre-post-studies 33 , and critical appraisal skills program (CASP) for cohort studies 34 specific to study design were used

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Additionally, a randomized trial of Vitamin D supplementation, which demonstrated a significant increase in serum vitamin D in treated participants, did not demonstrate a significant reduction in BV incidence vs