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My honest opinion: the signal is strong enough to warrant formal study, and it's frustrating that the economics of peptide research make that unlikely anytime soon

PubMed literature search: BPC-157 Starting point for primary literature and review records

A number of studies have indicated that there may be an imbalanced state of mitochondrial dynamics in animals that have been genetically modified to develop ALS

In practice it is sold in the US almost exclusively as an unregulated "research use only" chemical explicitly not intended for human consumption

Leptin, secreted by adipocytes in proportion to fat mass, and insulin, secreted by pancreatic beta cells in response to glucose levels, activate specific neurons to regulate calorie intake and energy consumption (Chen, Xiao, et al., 2022)