This routes limitation is related to the small dose that can be administered, which implies the need to design and formulate a drug with a high loading capacity [16], making the route effective only for very potent drugs [6]
Intended setting: Laboratory research use
[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Tepes M., Krezic I., Vranes H., Smoday I.M., Kalogjera L., Zizek H., Vukovic V., Oroz K., Kovac K.K., Madzar Z., et al
Thats the distinction that separates what Im describing here from the optimization-culture version of this conversation
This matrix acts as a nucleation scaffold, attracting and organizing calcium and phosphate ions from saliva into new hydroxyapatite crystals effectively rebuilding enamel from the inside out without drilling or restoration