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166 T2D has long been found mostly in adults, but it is increasingly common in adolescents and children due to the increase in obesity in these individuals

23 Increases in Itch/AIP4 levels and transcription in p53 wt Mel-29 cells and AIP5 in p53 mut Mel-23 cells suggested that the decrease in TAp73 was due to proteasomal degradation

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While tirzepatide is not primarily eliminated through the kidneys, the gastrointestinal effects of the medication, including potential nausea, vomiting, and diarrhea, could lead to dehydration and electrolyte imbalances that may be particularly problematic in patients with compromised kidney function