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Both these methylation reactions are vital for growth and cell reproduction.910 Methionine, a sulfur-containing, essential amino acid, is a precursor of S-adenosylmethionine, a cofactor for one-carbon metabolism and the final methyl donor for the methylation of DNA, RNA, proteins, and phospholipids.11 The methionine synthase plays a paramount role in the synthesis of nitrogenous bases (purines and pyrimidines) involved in the formation of DNA

2010 Jan 29;5(1):e8976 (4) Stark, C., Helenius, M., Taimen, P

K176 is also in the dimer-dimer interface and participates in interactions with E300 of the opposing subunit (Figure 7C)

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