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But like most beneficial peptides, plasma concentrations decline sharply with age from roughly 200 ng/mL at age 20 to around 80 ng/mL by age 60

Ther Drug Monit

Even then, advancements in formulation techniques can improve oral delivery systems

The skin is a formidable barrier, and most peptides cannot cross it without chemical enhancers, microneedles, or iontophoresis (electrical current)

[67] [68] This elongation is a result of ribosomal addition (via tRNAs brought by Rqc2) of CAT tails: ribosomes extend the C -terminus of a stalled protein with random, translation-independent sequences of a lanines and t hreonines