Interestingly, we observed a trend of increased levels of the pyrimidine nucleotide thymidine triphosphate (TTP) in irradiated cells ( p = 0.211), while irradiation led to a significant decrease of the cellular levels of uridine triphosphate (UTP) ( p = 0.012), the precursor nucleotide of TTP
doi:10.1016/0895-4356(94)90117-1 Franco R, Schoneveld OJ, Pappa A, Panayiotidis MI
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During the oxidation phase, accumulated ROS (such as hydrogen peroxide HO and superoxide anion O) in the cell can directly react with GSH in a non-enzymatic manner, or, under the catalysis of glutathione peroxidase (GPX), promote the oxidative coupling of two GSH molecules to form one molecule of GSSG, while releasing two protons (H) and two electrons (e)