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Signaling the mitochondrial unfolded protein response

In a study of 3,933 respondents diagnosed with POTS, 20% also had FM and 21% had ME/CFS, highlighting the overlap between these conditions (Vernino et al., 2021)

Also, when blood-brain barrier (BBB) is disrupted by stroke and other brain diseases, it helps to transfer the systemic iron pool into neurons in the brain parenchyma, exacerbating ferroptosis (DeGregorio-Rocasolano et al., 2019)

A reduced mitochondrial ROS, enhanced mitochondrial swelling, and suppression of mitochondrial membrane depolarization were additionally found

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