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If side effects persist beyond week 4 or worsen with dose escalation, reduce the dose by 20% and maintain that level for an additional 2 weeks before further increases

Neurosci Lett (2003) 335:1514

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A novel platform for the potentiation of therapeutic antibodies based on antigen-dependent formation of IgG Hexamers at the cell surface

Interestingly, aphid-fed dao1 DR5:GUS Arabidopsis leaves did not show more GUS activity than aphid-fed DR5:GUS Arabidopsis leaves