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An early research published at PubMed Central suggests that vitamin B12 supplementation can potentially reduce the risk of developing depression starting at the adolescent age

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4,5 Dietary insufficiency, pernicious anemia (i.e., an autoimmune process that reduces available intrinsic factor and subsequent absorption of vitamin B 12 1,2,6,7 ), and long-term use of metformin or acid-suppressing medications have been implicated in B 12 deficiency

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Some patients must continue to take supplements or receive injections for life depending on the reason for the deficiency