According to medical literature, glutathione functions as one of the body's most important antioxidant compounds and is naturally produced in cells throughout the body, with the highest concentrations found in the liver
Here's more about the importance of the gut-thyroid connection
doi: 10.1111/j.2042-7158.2011.01314.x
Nonetheless, when a cell (e.g., a hepatocyte) is exposed to inflammation or oxidative stress, NRF-2 has the capacity to escape from regulation by KEAP1 through the increase in the transcription of mRNA from NRF-2, with the objective of depleting the reserves of KEAP1, which cannot be recycled because of the suppression of another NRF-2 [21]

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