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Solute carrier family 7 member 11 (SLC7A11, also known as xCT) maintains cellular antioxidant capacity by synthesizing GSH, whereas the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway activates downstream genes, such as GPX4, SLC7A11 and heme oxygenase 1 to suppress ferroptosis (20,21)

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