Bioorg Med Chem Lett 22:18221826 Eaton JK, Furst L, Ruberto RA, Moosmayer D, Hilpmann A, Ryan MJ, Zimmermann K, Cai LL, Niehues M, Badock V, Kramm A, Chen S, Hillig RC, Clemons PA, Gradl S, Montagnon C, Lazarski KE, Christian S, Bajrami B et al (2020) Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles
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The medication should be injected subcutaneously into fatty tissue of the abdomen, thigh, or upper arm, with the abdomen often being preferred due to consistent absorption and ease of access
The glutathione binds with these substances and helps the liver transform them into a form that can be safely excreted through urine or bile
However, preterm and small-for-gestational-age infants have lower iron stores at birth due to reduced gestational iron accretion, making them more vulnerable to early-onset ID