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Initial correction of significant deficiency typically involves weekly or biweekly injections for several weeks until levels normalize and symptoms resolve

The peer-reviewed literature is also concentrated within a single research group (Watowich lab, University of Texas at Austin) and its industry partner Ridgeline Therapeutics, with limited independent replication to date

Since these supplements move through the digestive system, gut health and intrinsic factors play an important role in how much B12 the body absorbs

doi: 10.2337/diabetes.51.12.3368

A deficit in these B vitamins can make individuals sluggish, and chronically tired, and can also hinder weight loss efforts