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For source design and surface treatment, MOFs could be constructed using low-toxicity metals such as iron and gallium, and COFs could be composed entirely of light elements to prevent the release of toxic metal ions at the source, thereby avoiding the immunological risks associated with such releases

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Notably, KPV's impact seems concentrated in settings of heightened inflammation, with minimal effect on normal tissue

NAD+ supplementation (NAD+, NMN, NR) increases the supply of NAD+ precursors from outside the cell

Depending on the involvement and extent of pigmentation, the number of sessions may vary