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3 Interactions of autophagy with the cGAS-STING pathway 3.1 cGAS The interplay between autophagy and cGAS occurs through (i) cGAS-Beclin-1 interaction that promotes autophagic degradation of cytosolic dsDNA, (ii) cGAS-LC3 interaction that promotes micronucleophagy, and (iii) degradation of cGAS through p62-mediated selective autophagy ( Figure 3 )
1 and Extended Data Fig
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Furthermore, genetic studies suggest that heat stress during the summer months impedes embryo development, likely because altered expression under these conditions is associated with a reduced developmental capacity of oocytes and embryos 73
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