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In a chinchilla model of acute acoustic trauma, HPN-07 itself enhanced auditory/cochlear functional recovery, and reduced loss of cochlear HCs, afferent nerve fibers in the spiral lamina and fibrocytes within the spiral ligament 33

[36] This degradation process releases the drug payload specifically into cancerous or tumorous tissue, leveraging the significant difference in redox potential between the oxidizing extracellular environment and the reducing intracellular cytosol

The HGF system plays crucial roles in brain development and repair that diminish with age

J Vasc Res