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Artesunate attenuates bone erosion in rheumatoid arthritis by suppressing reactive oxygen species via activating p62/Nrf2 signaling

At the molecular level, the secret to glutathiones protective power lies in the sulfhydryl (-SH) group attached to its cysteine residue

Cystine regulates cellular GSH homeostasis Given that cysteine is an essential substrate for the synthesis of GSH 6 , we first evaluated whether intracellular GSH level is affected by cystine deprivation

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Therefore, it has been observed that the antioxidant capacity found in the cellular matrix may become reduced in critical clinical conditions, including septic shock, cardiac bypass surgery, and reperfusion injury after organ transplantation, and renal dialysis [216]