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This review is also significant because it positions GHK-Cu in the context of gene data from the Broad Institute's Connectivity Map the same database used by pharmaceutical researchers to discover new drug applications

8a and Supplementary Fig

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As for vascular growth, which is highly correlated with tumor development, bilirubin inhibits ERK activity in damaged blood vessels, and because ERK activation is associated with the mitogenic stimulation-induced cyclin D1 expression (102, 103), the reduction of ERK activity caused by bilirubin may be responsible for the down-regulation of cyclinD1 by bilirubin after arterial injury