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10.1016/j.theriogenology.2015.01.029 68 ItkinM.Davidovich-RikanatiR.CohenS.PortnoyV.Doron-FaigenboimA.OrenE.et al (2016)

The result in phase 2 clinical trials was 24.2% mean body weight reduction at 48 weeks with the 12mg dose, and the first phase 3 TRIUMPH-4 trial reported an average of 28.7% weight loss at 68 weeks

Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism

These therapies aim to enhance WL and improve metabolic outcomes by engaging multiple hormonal pathways, with preclinical and early-phase clinical trials supporting their potential as next-generation obesity treatments [16,17,18,19,20,21,22,23]

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