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Not only does the KP hijack tryptophan away from the serotonin pathway 28,30,31 , the metabolite kynurenine and oxidative stress also lowers the level of tetrahydrobiopterin (BH4) 1,55,56 , an important coenzyme of the serotonin pathway

New York: Elsevier, 2010:2356-2370 Bulun SE

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The enzymatic oxidation is catalyzed by a family of enzymes, such as cytochrome P450 (CYP), cyclo-oxygenase-2 (COX-2), peroxidase, tyrosinase (monophenol oxygenase), xanthine oxidase (XO), monoamine oxidase (MAO), and polyphenol oxidases (PPO), and is a reversible reaction using reducing agents such as H 2 or H 2 S [164]

2b1, b2 and 6a)