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Activation of liver AMPK with PF-06409577 corrects NAFLD and lowers cholesterol in rodent and primate preclinical models

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While probiotics are generally considered safe for short-term use, extended or indiscriminate consumption may lead to unintended consequences, particularly in specific populations, theoretical risks include systemic infections, immune overactivation, and metabolic disturbances, especially in immunocompromised or severely ill individuals (181)