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This feature has been extensively researched in human medicine, leading to the discovery that elevated PIVKA-II serum concentrations are suggestive of specific neoplastic illnesses, including HCC, and coagulative pathologies (70)

Executive dysfunction, linked to poor treatment response, relapse, and disability, is a critical treatment target

However, ferroptosis inducers cannot promote ferroptosis in all cancer cell lines, indicating that the genetic and metabolic susceptibility determinants limit the application of ferroptosis inducers in vivo

doi: 10.1016/j.phymed.2017.12.019 155 YangLLiuYNGuYGuoQ

Abstract 4135531: The ubiquitin-specific protease 30 inhibitor, MTX652, attenuates cardiac dysfunction and remodelling in a murine model of transverse aortic constriction