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The American Society for Reproductive Medicine (ASRM) committee opinion on smoking and infertility states that lower live birth rates were observed even when women who smoked used donor eggs (eggs from a younger, non-smoking woman) to create embryos, indicating that smoking may also have an impact on the uterus

The Kandels view these results as evidence to support their theory that "gateway drugs" such as tobacco, alcohol, and marijuana physiologically prime people to enjoy other psychoactive substances

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However, following the reference ranges for different user groups and prioritizing nicotine control are key to safe vaping

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