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These findings suggest that rosuvastatin mitigates I/R induced testicular damage primarily through modulation of key intracellular pathways, particularly PI3K/AKT, and support its therapeutic potential in acute testicular injuries and related degenerative conditions

Statistical analysis The results are presented as mean SD from at least three independent biological replicates, with all analyses performed using GraphPad Prism 7 (GraphPad Software, USA)

Host cytosolic glutathione sensing by a membrane histidine kinase activates the type VI secretion system in an intracellular bacterium

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