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Notably, primates who were treated at an adipotide dose of 0.43mg/kg daily for four weeks [1]: Exhibited normal levels of activity without any overt clinical signs of nausea, vomiting, or food aversion Showed normal lipid profiles that did not vary throughout the study Registered higher levels of serum creatinine from adipotide doses of 0.25mg/kg Increased urine, with mild dehydration being reported at the highest adipotide dose levels Most changes in the primates serum and urine were reversed within 28 days following discontinuation of treatment [1]

Some APIs are metabolised more than others during this first pass metabolism

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