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Methods Pure nicotine was obtained from Fluka, Switzerland

Nicotine: Starts clear, turns yellow/brown when exposed to air, affects gum health by shrinking blood vessels

Regulatory bodies such as the funding agency and/or Los Angeles County Department of Public Health Committee for the Protection of Human Subjects may have access to study data for the purpose of an audit to protect the rights and welfare of participants

A 2021 publication by the Campaign for Tobacco-Free Kids , a non-profit organization, stated that about 80% of the world's smokers lived in low and middle income countries, and that if current trends were to continue, about a billion people could die from smoking related diseases in the 21st century