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Sakurai T (2007) The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

It is worth noting that studies reported that hypoxiadriven stabilization of HIF1 enhances Gln metabolism by upregulating glutaminase expression and Gln transporter activity, thereby supporting redox homeostasis and cell survival under lowoxygen stress

Furthermore, HMGB1 release also confirmed that free OLE and PEG-T ECM -NS/OLE could efficiently induce immunogenicity of the tumour cells