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Moreover, oral treatment with NADPH oxidase antagonists mitigates the clinical and pathological features of parkinsonism in the MPTP marmoset model (Philippens et al., 2013)

Several studies mediated by the dopamine neurotoxin MPP + suggest mechanisms for Lf's potential neuroprotection and increased survival of DA cells with HSPG interaction

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However, as we discussed DAM and DAA, it remains largely unclear how reactive astrocytes, which originate from the neuroectoderm, acquire functional similarities, such as inflammatory responses and phagocytic activity, to immune cells like microglia and macrophages that arise from primitive hematopoietic progenitors and mesoderm-derived bone marrow hematopoietic cells

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