glutathione s transferase detoxification transferases as mediators of signaling pathways involved in cell proliferation and cell death The triple role of glutathione

Hodges, Romilly E., and Deanna M

Mitochondria are also involved in key cellular functions such as Ca 2 + homeostasis, heme biosynthesis, nutrient metabolism (Renault and Chipuk, 2013)

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Dludla PV, Nkambule BB, Nyambuya TM, Ziqubu K, Mabhida SE, Mxinwa V, Mokgalaboni K, Hanser S, Mazibuko-Mbeje SE, Basson AK, Sabbatinelli J, Tiano L (2022) Vitamin C intake potentially lowers total cholesterol to improve endothelial function in diabetic patients at increased risk of cardiovascular disease: a systematic review of randomized controlled trials

These data suggest that in the absence of GSH synthesis, the liver accumulates GSH precursors and can re-route them into alternative metabolic pathways