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Similarly, in pancreatic ductal adenocarcinoma (PDAC) and NALM-6 leukemia cells, membrane lipid remodeling involving polyunsaturated fatty acidcholesterol esters (PUFA-CEs)generated via the acyl-CoA synthetase long-chain family member 4 (ACSL4)sterol o-acyltransferase 1 (SOAT1) pathway and regulated by solute carrier family 47 member 1 (SLC47A1)drives ferroptotic sensitivity [59]

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The novel relationship between Sirt3 and autophagy in myocardial ischemia-reperfusion