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It is indistinguishable from the anemia associated with vitamin B12 deficiency ( Lack of vitamin B9 may also lead to birth defects of the brain or neural chord, collectively known as neural tube defects ( Side Effects and Toxicity No serious adverse effects of high vitamin B9 intake have been reported

The main clinical studies addressing the relationship between dietary habits and thyroid functional status and/or autoimmunity are summarized in Table 2

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doi: 10.1016/j.cmi.2018.03.042 [DOI] [PubMed] [Google Scholar] 205

As it was previously demonstrated that lysine lactylation was induced by neural excitation, a key molecular mechanism for the development of epilepsy [96], with the detailed results showing the positive association of increase of lysine lactylation and the expression of the immediate-early gene marker of neuronal activity c-Fos [97], it is hypothesized that histone delactylation by HDAC1-3 may inhibit the development of epilepsy and prevent seizures