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Differential gene expression in validation datasets A two-sided unpaired t -test was used to assess expression differences between conditions (PD, iLBD, and age-matched controls) and brain regions (R1R6) in the AHBA, UKBEC, and PD microarray dataset

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236 Bacteria-derived lipopolysaccharide (which is a canonical PAMP often used to instigate reactive astrogliosis and microgliosis) act as agonists of TLR2 and 4