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In addition, palbociclib led to a reduction of GPX4 and ferritin levels that likely contributed to increase ferroptosis vulnerability

10.1038/s41569-018-0030-z Summary Keywords D-Gal, endothelial cell senescence, FOXO4-DRI, P53, ROS Citation Hu Z, Li F, Hu C, Shan Q, Tang Z, Jiang M, Yi X, Chen X, Jin L, Wang X and Wang Y (2026) FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway

While GLP-1 and GIP receptor agonists are highly effective for initiating caloric deficits, human metabolism is highly adaptive