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Balcioglu M, Buyukbekar BZ, Yavuz MS, Yigit MV

(i) increased muscle protein breakdown

thermophilus CsoR one of the Cu I -coordinating Cys is replaced by a His, thus defining a xCH-H metal-binding motif (Figure 12B)

Key challengessuch as optimizing peptide design, ensuring biosafety, refining delivery systems, and improving preclinical modelsare critically analyzed

doi:10.1073/pnas.1002178107, PMID: 20713697 Adam-Vizi V, Chinopoulos C (2006) Bioenergetics and the formation of mitochondrial reactive oxygen species